Tethered thiazolidinone dimers as inhibitors of the bacterial type III secretion system
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چکیده
منابع مشابه
Small-Molecule Inhibitors of the Type III Secretion System.
Drug-resistant pathogens have presented increasing challenges to the discovery and development of new antibacterial agents. The type III secretion system (T3SS), existing in bacterial chromosomes or plasmids, is one of the most complicated protein secretion systems. T3SSs of animal and plant pathogens possess many highly conserved main structural components comprised of about 20 proteins. Many ...
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Many gram-negative plant and animal pathogenic bacteria employ a type III secretion system (T3SS) to subvert and colonize their respective host organisms. The T3SS injects effector proteins directly into the cytosol of eukaryotic cells and thus allows the manipulation of host cellular activities to the benefit of the pathogen. In plant pathogenic bacteria, T3SSs are encoded by hrp (for hypersen...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2009
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2009.01.047